Protective effects as ischemic preconditioning of sasanquasaponin mediated by K_(ATP) channel in the intact rat hearts 1
- VernacularTitle:K_(ATP)通道介导的油茶皂甙对在体大鼠心肌产生的缺血预适应样保护作用
- Author:
Qiren HUANG
;
Shouyi CAO
;
Ming HE
;
Ping LI
;
Weijie PENG
;
- Publication Type:Journal Article
- Keywords:
pharmacology;
sasanquanonion;
K ATP channel;
myocardial ischemic preconditioning;
cardioprotection
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study protective effects as myocardial ischemic preconditioning of sasanquasaponin (SQS) and its relationship with K ATP channel. METHODS: The study adopted the model of myocardial ischemic injury induced by subcutaneous injection of isoproterenol (ISO) in rats, administering specific K ATP channel blocker gliberclamide (GLI 5 mg?kg -1 ). Four groups were set as NS group, I/R group, SQS group ( 0.2 mg?kg -1 ), and GLI group (5 mg?kg -1 ). Prior to injection of ISO, all agents were intraveneously injected into rats for 3 days, one time per day. Subsequently, ISO was subcutaneuously injected into rats by the ways of many different sites, and some indices were measured including ECG, serum creatine kinase (CK) activity, free fatty acid (FFA), and adenosine contents in rats. RESULTS: Preconditioningly intravenous injection of SQS could effectively protect myocardium from ischemic injury induced by ISO. With GLI injected prior to SQS, the cardioprotective effects of SQS were significantly attenuated. CONCLUSION: SQS can protect myocardium from ischemic injury induced by ISO, and the protection may be mediated by K ATP channel.
