Protective effects of procyanidin on myocardial ischemia reperfusion injury in rats
- VernacularTitle:原花青素对大鼠心肌缺血再灌注损伤的保护作用
- Author:
Chenjing WANG
;
Mingtang GAO
;
Xiaoyan SHI
;
Yongjie WU
;
Wenguang LI
;
- Publication Type:Journal Article
- Keywords:
pharmacology;
procyanidin;
myocardial ischemia reperfusion;
lipid peroxide;
superoxide dismutase
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To inverstigate the protective effects of procyanidin on myocardial ischemia reperfusion injury in rats. METHODS: Myocardial ischemia reperfusion injury models were established by the ligation of left desending coronary artery for 40 min and referfusion for 120 min in rats, and the influence of procyanidin on enzymes of myocardial, myocardial infarction size and lipid peroxide were observed. RESULTS: Procyanidin decreased myocardial creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) release significantly diminished myocardial infarction size, raised the activity of superoxide dismutase (SOD), reduced malondialdehyde (MDA) content in myocardial and serum in comparison with the control. CONCLUSION: Procyanidin has a protective effect on myocardial ischemia reperfusion injury. The action is related to the inhibition of the free radical and subsequent lipid peroxidation.
