Pharmacokinetics of salvia miltiorrhiza injection in rats
- VernacularTitle:丹参注射液在大鼠体内的药动学研究
- Author:
Juan WANG
;
Zhangqing MA
;
Jianguo SONG
;
- Publication Type:Journal Article
- Keywords:
pharmacology;
salvia miltiorrhiza injection;
salvianic acid A;
pharmacokinetics;
HPLC
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate pharmacokinetics of salvia miltiorrhiza injection in rats. METHODS: A dose of salvia miltiorrhiza injection (standardized as Dhpl 40 mg?kg -1 , iv) was given in rats and plasma Dhpl concentrations were determined by a HPLC method. The 3p87 software was used to calculate the pharmacokinetic parameters of Dhpl. RESULTS: The main parameters were as follows: T 1/2? = 0.29 ? 0.23 h, T 1/2? = 1.75 ? 0.99 h, V d= 0.83 ? 0.70 L?kg -1 , Cl= 0.33 ? 0.16 L?h -1 ?kg -1 , and AUC (0-inf) =149?66 mg?h?L -1 . CONCLUSION: Data of the blood concentration time of salvia miltiorrhiza injection can be fitted to a two compartment open model.
