Dosage regimen design of intravenous bolus injection administration of two-compartment model based on Microsoft EXCEL
- VernacularTitle:基于EXCEL软件的二室模型静脉推注给药的给药方案设计
- Author:
Yinfa SU
;
- Publication Type:Journal Article
- Keywords:
pharmacology;
pharmacokinetics;
dosage regimen;
two compartment model;
EXCEL
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish a calculation of dosage regimen design on multiple dosing intravenous bolus injection administration of two compartment model. METHODS: Microsoft EXCEL was used to write a program by the pharmacokinetic parameters to show the dosage regimen. RESULTS: The e table displayed maximum dose (D max ) and minimum dose (D min ) of the administration after inputting parameters (?, ?, K 21 and V 1) ,dosing interval (T s), maximum toxic concentration(MTX) and minimum effective concentration(MEC). After inputting maintenance dose and cycle number (n), the e table displayed plasma concentration at any time after the administration, including C (n,s) max and C (n,s) min , fractional number of reaching plateau, loading dose and accumulating time when the plasma concentration was above MEC in Ts or a cycle interval. CONCLUSION: This design method can provide safe and effective dosage regimen for clinical administration.
