Glutamate transporter and neurodegenerative disorders
- VernacularTitle:谷氨酸转运体与神经退行性疾病
- Author:
Yanling YANG
;
Gang HU
;
- Publication Type:Journal Article
- Keywords:
pharmacology;
review;
glutamate transporter;
amyotrophic lateral sclerosis;
Alzheimer's disease;
Parkinson's disease
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Glutamate is the primary excitatory amino acid in the mammal brain. Glutamate transporters perform the regulation of glutamate levels in synaptic cleft. If the glutamate transporters should not be expressed, stopped working, or gone into reverse releasing glutamate from the cytoplasm, there would be an extracellular build up of glutamate. Defective glutamate uptake has been suggested to be important in connection with amyotrophic lateral sclerosis, Alzheimer's disease and Parkinson's disease.
