Hyperlipemia in sepsis —A part of non-adaptive host immune response
- VernacularTitle:脓毒症性高脂血症——机体先天性免疫反应的一部分
- Author:
Yunzhao ZHAO
;
Jieshou LI
;
- Publication Type:Journal Article
- Keywords:
Endotoxin;
LPS;
Hyperlipoproteinemia;
innate immunity
- From:
Parenteral & Enteral Nutrition
1997;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial endotoxin elicits dramatic responses in the host including elevated plasma lipid levels due to the increased synthesis and secretion of triglyceride (TG) rich lipoproteins by the liver and the inhibition of lipoprotein lipase. This cytokine induced hyperlipoproteinemia, clinically termed the lipemia of sepsis, was customarily thought to represent the mobilization of lipid stores to provide the fuel for the host’s response to infection. However, since lipoproteins can also bind and neutralize LPS, TG rich lipoproteins (VLDL and chylomicrons) are also components of non adaptive host immune response to infection. The studies are reviewed about the capacity of lipoproteins to bind LPS, protect against LPS induced toxicity and modulate the host response to the bacterial toxin.
