Effect of soman intoxication under hypoxia on the expression of M_2R mRNA of rat myocardium
- VernacularTitle:缺氧条件下梭曼中毒对大鼠心肌M_2受体mRNA表达的影响
- Author:
Hui LIU
;
Yong LIU
;
Shili WANG
;
Jiqing ZHAO
;
Qiang WU
;
- Publication Type:Journal Article
- Keywords:
hypoxia;
soman intoxication;
RT PCR;
muscarinic receptor
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
reression of M 2 receptor mRNA of rat myocardium intoxicated by soman under high altitude hypoxia. Methods The expressions of M 2 receptor mRNA under hypoxia, soman intoxication and soman intoxication under hypoxia were detected by semi quantitative RT PCR, respectively. Results The expression of M 2 receptor mRNA increased in the high altitude hypoxia group. Both simple soman intoxication and combined soman intoxication and hypoxia decreased the expression of M 2 receptor rapidly. But under hypoxia, the expression increased significantly at 12 h and 24 h. Conclusion M 2 receptor was sensitive to nerve agents. Compared to simple soman intoxication group, the expression of M 2 receptor increased in combined soman intoxication and hypoxia group. This may be one of the major factors leading to aggravation of the injury of heart function by nerve agents in high altitude area.
