The progress in LOX-1 research
- VernacularTitle:LOX-1研究进展
- Author:
Yujuan LI
;
Guanhua DU
;
- Publication Type:Journal Article
- Keywords:
LOX 1;
ox LDL;
atherosclerosis
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Lectin like oxidized low density lipoprotein receptor 1(LOX 1) is a type Ⅱ membrane protein belonging to the C type lectin family molecules which can act as a cell surface endocytosis receptor for oxidized LDL.LOX 1 can support binding, internalization and proteolytic degradation of oxidized LDL. And LOX 1 is involved in the platelet endothelium interaction and mediates phagocytosis of aged/apoptotic cells in endothelial cells ox LDL. Purification of soluble LOX 1 and the N terminal amino acid sequencing identified the two cleavage sites (Arg 86 Ser 87 and Lys 89 Ser 90 ). LOX 1 expression is not constitutive, but can be induced by proinflammatory stimuli, such as Angiotension Ⅱ, fluid shear stress and so on.
