Influence of tetrodotoxin on sodium channel and the possible mechanism of the analgesic effect
- VernacularTitle:河豚毒素对钠通道的影响及其可能的镇痛机制
- Author:
Ying XU
;
Yonghe ZHANG
;
Baoshan KU
;
- Publication Type:Journal Article
- Keywords:
tetrodotoxin;
sodium channel;
analgesic effect
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Tetrodotoxin(TTX) is a potent sodium channel blocker. It can affect the generation of action potentials of cell membranes by blocking sodium channel. Damaged tissues express a Tetrodotoxin resistant(TTX R) Na + current which provides a potential target for therapeutic intervention in a range of pain states. We summarize the influence of tetrodotoxin on sodium channel and the possible mechanism of the analgesic effect.
