Complicated and diverse effects of agmatine on central nervous system
- VernacularTitle:胍丁胺中枢作用的复杂性及多样性
- Author:
Xiechuan WENG
;
Jianquan ZHENG
;
Jin LI
;
Wenbin XIAO
;
- Publication Type:Journal Article
- Keywords:
agmatine;
neurotransmitter;
imidazoline receptor;
ligand
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Agmatine was first identified and characterized as a candidate for CDS (clonidine displacing substance) in the bovine brain in 1994. The following researches demonstrated that agmatine was a widely distributed endogenous substance and performed a lot of biological functions in the central nervous system. The evidences revealed its targets were diverse and its mechanisms were complicated. Now it is well accepted that agmatine is a new neurotransmitter and/or neuromodulator and it might be an endogenous ligand of imidazoline receptor.
