Effects of neurotrophic factors on ischemic damage and the regulation by medicines
- VernacularTitle:神经营养因子对缺血性脑损伤的影响及其药物调节
- Author:
Yuyang ZHANG
;
Qinghai YU
;
- Publication Type:Journal Article
- Keywords:
neurotrophic factors;
ischemia;
excitotoxicity;
neurons;
regulation of medicines
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Neurotrophic factors are proteins that play an important role in the development and maintenance of neural networks. They released in the brain's response to injury and in neurodegenerative disorders and took part in the protective process. The fact that they can be used to prevent damage to neurons associated with brain lesions in animal models of neurodegenerative disorders supports the above mentioned hypothesis as well. However, they are proteins that do not easily cross the blood brain barrier. The induction of neurotrophic factors by systemically administered some medicines would be an elegant way to overcome problems of application.
