Effects of recombinant human interleukin-1 receptor antagonist on guinea-pig isolated airway smooth muscle
- VernacularTitle:重组人白细胞介素-1受体拮抗药对豚鼠离体呼吸道平滑肌的影响
- Author:
Jiping LI
;
Xiaoqun GE
;
Hongquan ZHANG
;
- Publication Type:Journal Article
- Keywords:
interleukin 1 receptor antagonist;
histamine;
ovalbumin;
isolated airway smooth muscle
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of recombinant human IL 1 receptor antagonist (IL 1ra) on isolated airway smooth muscle tissue. METHODS Changes of isolated organ's tension were monitored with force displacement transducer and MedLab recording system. RESULTS ①IL 1ra haddirect relaxant effect in normal and ovalbumin sensitized pulmonary as well as tracheal smooth muscle. The mean EC 50 values were 1 29?10 -8 mol?L -1 and 8 06?10 -8 mol?L -1 in normal pulmonary and tracheal smooth muscle, but the mean EC 50 values were 2 61?10 -7 mol?L -1 and 5 88?10 -7 mol?L -1 in ovalbumin sensitized pulmonary and tracheal smooth muscle. Therefore the relaxation responses of sensitized airway smooth muscle to IL 1ra were lower than those of normal pulmonary and tracheal smooth muscle.②IL 1ra(10 -9 ～10 -5 mol?L -1 ) concentration dependently inhibit contraction responses to histamine(10 -3 mol?L -1 ) in normal pulmonary and tracheal smooth muscle, compared with administrating solvent PBS group ( P
