Studies on analgesic effect of 1,6-Di-(4-phenethyl-1-methyl-1-piperazinyl)hexane dibromide
- VernacularTitle:1,6-二(4-苯乙基-1-甲基-1-哌嗪基)己烷二溴化物的镇痛活性研究
- Author:
Hongmei ZHANG
;
Changling LI
;
Runtao LI
;
- Publication Type:Journal Article
- Keywords:
piperazines;
1,6 Di (4 phenethyl 1 methyl 1 piperazinyl)hexane dibromide;
analgesia;
opioid receptor
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the analgesic effect of 1,6 Di (4 phenethyl 1 methyl 1 piperazinyl) hexane dibromide (97 9 G4) and its mechanisms. METHODS The writhing model of mice induced by acetic acid, hot plate test (sc, icv), tail flick test and the model of electrical stimulation induced contraction of guinea pig ileum were used. RESULTS The inhibition of writhing reaction induced by acetic acid was found (ID 50 =8 8 mg?kg -1 ) and the rising of mice pain threshold in hot plate test and in tail flick test was obvious ( P
