Effects of Di-p-Cl-benzoyl-linesinine on experimental arrhythmia
- VernacularTitle:二对氯苯甲酰莲心碱对实验性心律失常的影响
- Author:
Hui WANG
;
Shunde LUO
;
Jian YANG
;
- Publication Type:Journal Article
- Keywords:
di p Cl benzoyl linesinine;
arrhythmia;
aconitine;
ouabain;
CaCl 2
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM The purpose is to study the effect of Di p Cl benzoyl linesinine on experimental arrhythmias. METHODS The models used were caused by aconitine, ouabain and CaCl 2 repectively. RESULTS Di p Cl benzoyl linesinine 5 mg?kg -1 could increase the threshold dose of ventricular ectopic(VE), ventricular tachyacardia(VT), ventricular fibrillation(VF) and cardiac arrest(CA) caused by aconitine in rats and that by ouabain in ginuea pigs; delay the onset time of arrhythmia and decrease the incidence of VE,VF and CA induced by CaCl 2 in rats. CONCLUSION Di p Cl benzoyl linesinine possesses extensive effects of antiarrhythmia on ventricle.
