Hypoglycemia effect of sodium orthovanadate on diabetes rats
- VernacularTitle:原钒酸钠对Ⅱ型糖尿病的降糖作用研究
- Author:
Jie DU
;
Jing AI
;
Baofeng YANG
;
- Publication Type:Journal Article
- Keywords:
sodium orthovanadate;
streptozocin;
diabetes;
hypoglycemic action
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the anti hyperglycemic effect of sodium orthovanadate on type 2 diabetes rats. METHODS Rats were fed by highly fatted food to grow into obesity. Then values of plasma free fatty acid (FFA) were tested. Glucose disposal was measured with the hyperinsulinemic euglycemic clamp technique to assess insulin resistance in vivo. Small dose of streptozocin was injected ip with insulin resistance. Those with plasma glucose over 11 1 mmol?L -1 were assigned to type 2 diabetes model group, continually fed with sodium orthovanadate for 3 days and assayed the values of plasma glucose in fasting state. RESULTS ①Rats fed with fatted food needed more insulin to maintain normal plasma glucose, ie (0 54?0 02) U?min -1 , higher than that of normal control ( P
