THE ANTIMUTAGENIC CHARACTERISTICS OF FLAVONOIDS AND VITAMINS
- VernacularTitle:类黄酮和维生素的抗突变研究
- Author:
Yuanjing FAN
;
- Publication Type:Journal Article
- Keywords:
catechins;
flavonols;
phenolic acid;
vitamins;
caffeine;
1 NP;
Trp P 1;
antimutagenicity
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To contrast and analyse the antimutagenic activities and behavioral trait of flavonoids and vitamins. Methods:Modified Ames method using 1 nitropyrene (1 NP) as direct mutagen and 3 amino 1,4 dimethyl1 5H pyridoindole (Trp P 1) as indirect mutagen, Salmonella typhimurim TA98 were used. 6 kinds of catechins, 4 of flavonols and 5 of phenolic acid, vitamin C, vitamin A and series of vitamin B as well as caffeine were tested. Results: The antimutagenic activities against indirect mutagen (Trp P 1) of catechins, flavonols and phenolic acids were powerful than against direct mutagen (1 NP). Contrarily vitamins inhibited 1 NP from inducing mutation more strongly than from Trp P 1, and displayed dose effect relationship. Caffeine had no mutagenesis, but it was possibly antagonistic, when mixed with catechins. Conclusion:Flavonoids are very helpful for antimutagenicity against xenobiotics, especially for indirect mutagen , and vitamins conduce to assistant and complementary functions.
