The association of the expressions of CK20 mRNA, CD44v6 and P53 with abdominal cavity metastasis of colorectal cancer and the related significance
- VernacularTitle:结直肠癌腹腔转移与CK20 mRNA、CD44v6和P53表达及意义
- Author:
Nianxu SUN
;
Dehu WANG
;
Chao ZHANG
;
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
CK20mRNA;
CD44v6;
P53
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of abdominal cavity metastasis of colorectal cancer with the expressions of CK20 mRNA, CD44v6 and P53 and the related significance. Methods CK20 mRNA in peritoneal fluid was detected by reverse transcription polymerase chain reaction (RT PCR) and proteins of CD44v6 and P53 in cancer tissues were examined immunohistochemically in 50 cases of colorectal cancer. Results Significant correlation was found between CK20 mRNA and the expressions of CD44v6 and P53 in cancer tissues. Conclusion The detection of CK20 mRNA in peritoneal fluid plus examination of CD44v6 and P53 in cancer tissues are helpful for the prediction of abdominal cavity metastasis of colorectal cancer and post operation treatment.
