~1H MR spectroscopy of C6 glioma after tumor necrosis factor-?therapy
- VernacularTitle:肿瘤坏死因子作用于大鼠C6胶质瘤的~1H磁共振波谱研究
- Author:
Hong YIN
;
Yuangui GAO
;
Xiang ZHANG
;
Dakuan GAO
;
Xia LI
;
Haitao ZHAO
;
- Publication Type:Journal Article
- Keywords:
Glioma;
Tumor necrosis factor;
Nuclear magnetic resonance;
Animal,laboratory
- From:
Chinese Journal of Radiology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic effect of tumor necrosis factor ?(TNF ?) on C6 glioma using 1?H MR spectroscopy, and to evaluate the practical value of 1?H MR spectroscopy in observing therapeutic effect Methods C6 cell mixed with low boiling point argarous were inoculated in caudate nuclear in 33 rats by using sterotatic method By using high magnetic field spectrometer, high resolution 1?H MR spectroscopy was carried at a 3 day interval until 15 days after treatment with TNF ? The relative choline containing compound (Cho),N acetyl aspartate (NAA),creatine (Cr), Cho/Cr,NAA /Cr,and NAA/Cho were analyzed with statistic method Results The Cho decreased obviously 3 days after TNF ? treatment( P
