Progress in visceral hypersensitivity in irritable bowel syndrome
- VernacularTitle:肠易激综合征内脏高敏感性研究现状和展望
- Author:
Zhaoshen LI
;
- Publication Type:Journal Article
- Keywords:
irritable bowel syndrome;
visceral hypersensitivity;
brain gut axis
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Irritable bowel syndrome(IBS) is a functional bowel disorder characterized by abdominal discomfort and altered bowel habits.Techniques applicable to evaluate the visceral hypersensitivity associated with brain gut dysfunction in IBS can be grouped under 3 headings: visceral perception,reflex responses and central responses.And visceral hypersensitivity has been proved to be a pathophysiological characteristic of patients with IBS.The exact mechanisms of visceral hypersensitivity in patients with IBS are unknown,perhaps involving supersensitive mechanoreceptor and primary afferents in the intestinal wall,transient or long term changes in peripheral and central pathways.Abnormal central excitability and nerve mast cell communication may be the trigger of visceral hypersensitivity in IBS.In summary,a variety of different mechanisms in brain gut axis,alone or in combination,may be responsible for visceral hypersensitivity.Some of these mechanisms have been characterized in animal models of hyperalgesia.Recent breakthroughs in the neurophysiology of visceral sensation provided clue on the development of visceral hypersensitivity about the candidate neurotransmitter, which involving brain gut interaction.Advanced investigation would give us more precise results in brain gut axis to explain the visceral hypersensitivity of IBS in future.
