A study of the specific cytotoxic T cell of BALB/c mice detected by LDH
- VernacularTitle:LDH检测BALB/c小鼠CTL活性的初步研究
- Author:
Qiaoyu MA
;
Yuming WANG
;
Fei HAO
;
- Publication Type:Journal Article
- Keywords:
lactic dehydrogenase;
cytotoxic T cell;
BLAB/c mice
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a simple animal model and the cytotoxic T cell(CTL) detecting system for the studies of the effects of CTL on HCV infection. Methods The CTL activity in BLAB/c mice immunized by polypeptides in the core region of HCV was detected with lactic dehydrogenase (LDH) by using SP2/O cells as the target cells. Results CTL activity in BLAB/c mice immunized by polypeptides in the core region of HCV could be detected with LDH. The activity could be enhanced by CPA10(5～23 aa) but inhibited by CPA9(39～74 aa). Conclusion CTL activity in BLAB/c mice can be detected stably by LDH.
