Effects of TNF? on 26S proteasome and 19S regulator in skeletal muscle of the severely scalded rats
- VernacularTitle:TNF?对烫伤大鼠骨骼肌26S蛋白酶复合体及19S调节复合体的作用
- Author:
Yinling TAN
;
Shiliang WANG
;
Yanling DONG
;
- Publication Type:Journal Article
- Keywords:
burns;
TNF?;
26S proteasome;
19S regulator
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of negative nitrogen balance in the treatment after burns. Methods The means of immuno precipitation deduction and ELISA were used to test the activities and contents of 26S proteasome and 19S regulator in skeletal muscle of rats inflicted with 30%TBSAⅢ burns. Results TNF? markedly raised the activities and contents of 26S proteasome and 19S regulator in skeletal muscle after scalding. Conclusion TNF? activates the 26S proteasome system in skeletal muscle, thus it enhances the degradation of protein, which is associated with the development of negative nitrogen balance following scalding.
