Effect of morphine on the changes of intracellular free calcium in cultured hippocampal astrocytes in rat
- VernacularTitle:吗啡对大鼠海马星形胶质细胞[Ca~(2+)]i的影响
- Author:
Jiaxiang XIONG
;
Haidi LI
;
Xicheng LI
;
- Publication Type:Journal Article
- Keywords:
morphine;
astrocyte;
tolerance;
naloxone;
[Ca 2+ ]i
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). Spike of [Ca 2+ ]i of astrocytes was induced by acute morphine administration, but the spike of [Ca 2+ ]i of astrocytes pretreated with morphine could be induced only by higher concentration of morphine. The [Ca 2+ ]i response of astrocytes to morphine could be blocked by naloxone but not by MK 801(NMDA receptor antagonist). Conclusion The response of [Ca 2+ ]i in morphine induced astrocytes may play an important role in morphine tolerance.
