Genetic linkage analysis of localizing an autosomal dominant retinitis pigmentosa gene in a family
- VernacularTitle:遗传连锁分析法对一常染色体显性遗传性视网膜色素变性家系的基因定位研究
- Author:
Xiaoye MA
;
Ruili WEI
;
Jiping CAI
;
Li ZHU
;
- Publication Type:Journal Article
- Keywords:
gene;
localization;
retinitis pigmentosa;
linkage(genetics)
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To localize the gene of autosomal dominant retinitis pigmentosa(ADRP) in a family. Methods: A large ADRP family was studied and 3 5 ml of venous blood from some family members was collected, and genomic DNA was extracted from the blood. Then two point linkage analysis between the known markers and the disease locus was performed. Results: Linkage analysis showed the maximum LOD score reached 2.732852 at marker D3S1292 (at recombination fraction ?=0.1). Conclusion: The gene responsible for ADRP is located in 3q21 eara.
