Tissue microarray in studying difference of cell proliferation and microvessel density between hepatic malignant and benign lesions
- VernacularTitle:组织芯片技术研究肝脏良恶性病变细胞增殖活性和微血管密度的差异
- Author:
Jianping LU
;
Tao WANG
;
Yi WANG
;
Weiqing WU
;
Xinyuan GUAN
;
Jian WANG
;
- Publication Type:Journal Article
- Keywords:
liver neoplasms;
tissue microarray;
cell proliferation;
microvessel density
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the difference of the cell proliferation activity and microvessel density (MVD) between hepatic benign and malignant lesions for further demonstrating the biological features of tumor. Methods: There were 290 specimens of hepatocellular carcinoma (HCC), 128 specimens of cirrhosis tissues and 25 specimens of hepatic benign lesions were detected for PCNA, Ki 67 and MVD by immunohistochemistry on tissue microarray, respectively.Results: The expression level of PCNA and Ki 67 in HCC were 90.2% and 43.1%, which was obviously higher than that in cirrhosis (48.5% and 3.9%, P 0.05). MVD counting in HCC pathological grade Ⅰ Ⅱ(29.9?18.6) was higher than those in gradeⅢ (22.2? 18.2) and Ⅳ(22.9?19.0, P
