The role of antimicrobial peptides in immune system
- VernacularTitle:多肽抗生素在免疫系统中的作用
- Author:
Wenlin HAO
;
Chao SUN
;
Jingsheng LIU
;
- Publication Type:Journal Article
- Keywords:
antimicrobial peptides;
innate immunity;
inflammation;
sepsis
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Many species of animals contain antimicrobial peptides as components of their immune systems. Many antimicrobial peptides have a broad spectrum of activity not only against gram negative and gram positive bacteria but also against antibiotic resistant bacteria, fungi, viruses, and parasites. Such peptides can act in synergy with other host molecules to kill pathogens. It has been found that certain peptides have a high affinity for bacterial products, allowing them to modulate the host inflammatory response to sepsis. They have also been found that they have the ability to recruit inflammatory cells. These properties as well as some other functions of antimicrobial peptides enable them to have an important impact in innate immunity.
