The effects of Deketoprofen trometamol on adjuvant arthritis and gastroduodena
- VernacularTitle:右酮洛芬氨丁三醇对佐剂性关节炎大鼠的治疗作用及胃肠道损伤作用的研究
- Author:
Yong JIN
;
Jun LI
;
Yunfang ZHANG
;
Shu GAO
;
Shuyun XU
;
- Publication Type:Journal Article
- Keywords:
Deketoprofen trometamol (D KPT);
adjuvant arthritis (AA);
inflammatory
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the therapeutic effects of Deketoprofen trometamol (D KPT) on adjuvant arthritis (AA) and its side effects on gastroduodena. METHEDS The change of primary and secondary inflammatory and the injury effect of gastroduodena treated with D KPT were observed. The effect of D KPT on prostaglandin E 2 (PGE 2) produced by peritoneal macrophage (PM) on AA rats in vitro was also observed. RESULTS D KPT (2 5, 5, 10 mg?kg -1 ) significantly inhibited primary inflammatory, secondary inflammatory and multiple arthritis of AA rats. D KPT(10 -8 ,10 -7 ,10 -6 ,10 -5 ,10 -4 mol?L -1 )inhibited the elevated PGE 2 released from PM of AA rats in vitro . D KPT (10 mg?kg -1 ) significantly injured gastroduodena on AA rats, but the degree of injuries was less than that of ketoprofen (KP) (10 mg?kg -1 ). CONCLUSION D KPT has therapeutic effects on AA rats, and its injury effect on gastroduodena is less than that of KP.
