Antioxidation of metabotropic glutamate receptors ligand on unilateral substantia nigral 6-hydroxydopamine lesioned rat
- VernacularTitle:亲代谢型谷氨酸受体配基对黑质6-羟基多巴损毁大鼠的抗氧化作用
- Author:
Bing GU
;
Yingdong ZHANG
;
Gang HU
;
- Publication Type:Journal Article
- Keywords:
metabotropic glutamate receptors;
Parkinson disease;
antioxidation;
reactive oxygen species;
glotathione
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the antioxidation of metabotropic glutamate receptors (mGluRs)ligand on rat models of Parkinson disease. METHODS The rat models of Parkinson disease were established by employing 6 hydroxydopamine to lesion unilateral substantia nigral. The serum total antioxidative capability (T AOC), reactive oxygen species (ROS) inhibition competence and content of glotathione (GSH) were measured with chemical colorimetry. RESULTS Compared with control group, serum T AOC and GSH and ROS inhibition competence increased in all treatment groups, mGluRs antagonist (SIB 1893) group, mGluRs agonists (APDC ) group, mGluRs agonists ( L SOP) group and L DOPA group. The effect of APDC was most prominent. CONCLUSION mGluRs antagonist and mGluRs agonists may exert a partial antioxidation effect on unilateral substantia nigral 6 hydroxydopamine lesioned rat and may be beneficial to the body for alleviating the oxdative stress.
