Role of serotonergic projection from dorsal raphe nuclei to basolateral amygadaloid in regulation of sleep
- VernacularTitle:中缝背核投射到基底外侧杏仁核的5-羟色胺能纤维对睡眠的调节作用
- Author:
Lezhang ZHAO
;
Jun GAO
;
Jingxing ZHANG
;
Gongliang ZHANG
;
Mingkui ZHONG
;
Jin ZHANG
;
- Publication Type:Journal Article
- Keywords:
dorsal raphe nuclei (DRN);
basolateral amygadaloid (BLA);
serotonin (5 HT);
polysomnography(PSG);
sleep;
rat
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the role of serotonergic projection from dorsal raphe nuclei (DRN) to basolateral amygadaloid (BLA) in the regulation of sleep and waking state. METHODS stereotaxic microinjection and polysomnography were employed. RESULTS Microinjection of L Glu into the DRN caused an enhancement of wake (W) and a decrease of slow wave sleep (SWS) and paradoxical sleep (PS). However, microinjection of L Glu into the DRN plus bilateral microinjection of methysergide (MS) into the BLA reversed the effects of L Glu. Microinjection of PCPA into the DRN caused an enhancement of SWS and a decrease of W. Microinjection of PCPA into the DRN plus bilateral microinjection of 5 HTP into the BLA reversed the effects of PCPA. CONCLUSION These results suggest that the role of the DRN in the regulation of sleep and waking state is partly mediated by serotonergic projection from the DRN to the BLA.
