Protective effects of (-)-epigallocatechin-3-gallate on renal ischemia-reperfusion injury
- VernacularTitle:表没食子儿茶素没食子酸酯对肾缺血再灌注损伤的保护作用
- Author:
Gang LIANG
;
Juen HIANG
;
Xiao ZHANG
;
Xingguang LIAO
;
Ying XU
;
Renbin HUANG
;
- Publication Type:Journal Article
- Keywords:
(-)-epigallocatechin 3 gallate;
renal ischmia reperfusion injury;
antioxidant activity
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the protective effects of ( ) epigallocatechin 3 gallate (EGCG) against renal ischmia reperfusion injury. METHODS The renal ischemia reperfusion injury model in rat was made by means of ligating bilateral renal arteries for 60 min and then reperfusion. 10 mg?kg -1 and 40 mg?kg -1 EGCG were given by intravenation before and after operation respectively. Spectrophotometric assay were used to measure the contents of serum creatinine(Scr), blood urea nitrogen (Bun) in serum and the activity of superoxide dismutase (SOD) and Ca 2+ ATPase ,the contents of malondialdehyde (MDA), reactive oxygen species (ROS) in renal hemogenate from rats. Renal pathologic changes were also observed. RESULTS Compared with model control group , 40 mg?kg -1 EGCG group was found of significant inhibition in changes of Scr, Bun,MDA,ROS and significant increases in activity of SOD and Ca 2+ ATPase.The renal morphological injury of EGCG groups were slighter than that of model control group. CONCLUSION EGCG has protective effects aganist renal ischemia reperefusion injury via its antioxidant activity and intracellular caclcium reduction.
