Effects of ginkgo biloba extract on expressions of NSE S-100 mRNA in newborn rat brain with hypoxic-ischemic brain damage
- VernacularTitle:银杏叶提取物对新生鼠缺血缺氧性脑损伤NSE S-100 mRNA表达的影响
- Author:
Lin HOU
;
Haiping PU
;
Boqin SHAO
;
- Publication Type:Journal Article
- Keywords:
ginkgo biloba extract;
hypoxic ischemic brain damage;
neuron specific enolase;
S 100 protein;
newborn rat
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
ALM To study the effects of ginkgo biloba extract (GbE) on expressions of neuron specific enolase (NSE) and S 100 protein(S 100) mRNA in newborn rat brain after hypoxic ischemic brain damage (HIBD) and the mechanism of GbE against HIBD. METHODS The dynamic changes of expressions of NSE S 100 mRNA in brain tissue and effects of GbE were studied using 7 d SD rat hypoxic ischemic brain damage model and RT PCR techniques. RESULTS The peak expressions of mRNA for NSE and S 100 occurred 24 and 48 hours after HIBD respectively, and their expressions decreased gradually. The expressions of mRNA for NSE S 100 in 24, 48, 72 hours were increased after treatment with GbE ( P
