Effects of chronic low lead exposure on NMDA receptor subunit 1 mRNA in hippocampus in rats at the developmental stage
- VernacularTitle:慢性低水平铅暴露对发育期大鼠海马NMDAR-1 mRNA表达的影响
- Author:
Dagan FU
;
Huaqiang LI
;
Yuan SHI
;
Dongbo JIANG
;
- Publication Type:Journal Article
- Keywords:
lead;
hippocampus;
NMDAR 1 mRNA
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of chronic low lead exposure on molecular pathological mechanisms of learning and memory of rats at the developmental stage Methods The changes of N methyl D aspartate receptor 1 (NMDAR 1) mRNA expression in rat hippocampus were observed by using digoxigenin labled anti sense oligonucleotide probes in situ hybridization technique Results The changes in NMDAR 1 mRNA levels in Pb exposed rat hippocampus were found to be dependent upon the developmental period of exposure and the region of the hippocampus analyzed Hippocampal NMDAR 1 mRNA levels increased significantly in the CA1 (18 75%) and CA3 (13 2%) ( P
