Effect of H_2O_2 on transient outword potassium current in the cultured rat hippocampal neurons
- VernacularTitle:过氧化氢对培养大鼠海马神经元瞬时外向钾电流的影响
- Author:
Hongwei JIN
;
Wei ZHANG
;
Xiaoliang WANG
;
- Publication Type:Journal Article
- Keywords:
H 2O 2;
potassium channel;
patch clamp;
hippocampal neuron
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effects of H 2O 2 on transient outward potassium current METHODS Whole cell patch clamp technique was used to record changes of I A in the cultured rat hippocampal neurons RESULTS After exposure to 30 ?mol?L -1 H 2O 2 for 12 h (1) decreased I A current density from (53 8?15 8) PA?PF -1 to (18 5?6 2) PA?PF -1 ( n=10,P
