The study of piper futokadsura neoligans on brain protection after cerebral ischemia and reperfusion in rats
- VernacularTitle:海风藤新木脂素类成分对缺血再灌注鼠脑损伤的保护作用
- Author:
Xuesong WANG
;
Wei WANG
;
Xuzhong RUAN
;
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
piper futokadsura neoligans;
brain protection
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To compare the effect of Piper Futokadsura Neoligans with Ginkgolides, a platelet activiting factor receptor antagonist, on cerebral ischemic area,region cerebral blood flow(rCBF) and neuroligic function deficits following focal cerebral ischemia/reperfusion in rats. METHODS The middle cerebral artery (MCA) focal cerebral ischemia and reperfusion rat models were used. The cerebral ischemic area, rCBF and neural function deficits were measured by TTC staining,hydyogen clearance and neurologic function scoring, respectively. RESULTS A significant reduction in infarct volume were found in the Piper Futokadsura Neoligans treated group as well as in the Ginkgolides treated group compared with the control group.Furthermore, Piper Futokadsura Neoligans induced significant amelioration of the rCBF decrease and neurologic dysfunction following focal cerebral ischemia and reperfusion in rats. CONCLUSION Both Piper Futokadsura Neoligans and Ginkgolides have remarkable brain protective effects.
