The influence of chronic stress on the level of CNTF and CNTF mRNA in hippocampal neurons of rats
- VernacularTitle:慢性应激对大鼠海马神经元睫状神经营养因子及其mRNA表达水平的影响
- Author:
Xueqi WANG
;
Changlin LU
;
Jian SHI
;
Xiaohua DENG
;
Cheng HE
;
- Publication Type:Journal Article
- Keywords:
stress;
rat;
hippocampus;
CNTF
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the influence of chronic stress on the level of CNTF and CNTF mRNA in hippocampal neurons of rats. METHODS The chronic stress model was established by chronic unpredictable mild stress, openfield test was performed to detect the behavior of rats. Immunohistochemistry and in situ hybridization were used to observe the level of CNTF and CNTF mRNA. RESULTS Compared to control group, the CNTF like immunoreactivity and signals of CNTF mRNA in situ hybridization in the hippocampal neurons of chronic stress group were significantly decreased. CONCLUSION These results show that chronic stress can significantly decrease the level of CNTF and CNTF mRNA in the hippocampal neurons of rats.
