Effect of pinacidil on nicotine-induced current in rat superior cervical ganglia
- VernacularTitle:吡那地尔对培养大鼠交感神经元烟碱电流的影响
- Author:
Qin WAN
;
Zhipu LUO
;
Hai WANG
;
- Publication Type:Journal Article
- Keywords:
pinacidil;
nicotinic current;
superior cervical ganglia
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the effect of ATP sensitive potassium channel(K ATP ) opener pinacidil on the current induced by nicotine in cultured rat superior cervical ganglia. METHOD Whole cell patch clamp technique. RESULTS Pinacidil inhibited nicotine induced current when in higher dose(100 ?mol?L -1 ), but had no effect on the desensitization of nicotinic receptors. K ATP antagonist glibenclamide didn't influence the inhibitory effect of pinacidil on nicotinic current. CONCLUSION Pinacidil had an inhibitory effect on nicotine induced current in rat superior cervical ganglia and this effect wasn't mediated by K ATP .
