Anti-inflammatory and immunomodulatory actions of TGM and its mechanism
- VernacularTitle:丹皮总苷的抗炎免疫作用及部分机制研究
- Author:
Wenlu TANG
;
Jun LI
;
Shuyun XU
;
- Publication Type:Journal Article
- Keywords:
total glucosides of mudan cortex;
adjuvant arthritis;
immunoregulation
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the anti inflammatory and immunomodulatory actions of total glucosides of Mudan cortex(TGM)on adjuvant arthritis(AA)rats and its mechanisms. METHODS To observe the change of secondary inflammation and immune function on AA rats treated with TGM and to detect the effect of TGM on immune function in normal and AA rats in vitro. RESULTS TGM (25,50,100 mg?kg -1 ig) could significantly inhibit secondary inflammatory reaction(secondary inflammatory swelling, multiple arthritis, pathologic change of AA rats ankle arthrosis)of AA rats. Among them, TGM 50 mg?kg -1 ig had the best therapeutic effect, and could make the weight of atrophied thymus of AA rats restore to normal. Treated with TGM ig, not only the lower response of splenocytes to Con A and decreased IL 2 synthesis of AA rats were restored to normal but also the elevated IL 1 synthesis and PGE 2 release of PM? were reduced. The production of IL 1 by LPS induced PM? from normal rats were enhanced by in vitro treatment with lower concentrations (0 4～10 mg?L -1 )of TGM, but diminished with higher concentrations(50～250 mg?L -1 )of it. The production of PGE 2 were increased with dose independent manner(TGM 0 4～250 mg?L -1 ). In the range of 10～250 mg?L -1 TGM in vitro could significantly decreased the production of IL 1 and PGE 2 from AA rats and enhanced Con A induced proliferative response of splenocytes and IL 2 synthesis from splenocytes of AA rats. CONCLUSION TGM has anti inflammatory and immunomodulatory actions on AA rats mainly through inhibiting cell mediated immunity.
