Alterations in chronobiology of salivary cortisol and melatonin in nocturnal asthma
- VernacularTitle:唾液中游离皮质醇和松果体素水平昼夜节律性变化与夜间哮喘相关性研究
- Author:
Guanghe FEI
;
Rongyu LIU
;
Jiangning ZHOU
;
- Publication Type:Journal Article
- Keywords:
saliva;
cortisol;
melatonin;
circadian rhythm;
nocturnal asthma
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the relationships between the alterations in circadian rhythms of cortisol, melatonin and nocturnal asthma METHODS Circadian rhythms of salivary free cortisol and melatonin levels were investigated in 15 control subjects and 8 exacerbation and 7 remission patients with bronchial asthma The serial salivary samples were collected at 12 time points during a 24 hour period The intensity of illumination was restricted to 50 lux during the night Salivary cortisol and melatonin levels were measured by radioimmunoassay RESULTS The 24 hour mean levels (mesor) of salivary cortisol was significantly different by one way ANOVA among the three groups ( P
