The Change of PAC-1 and P-selectin Expression after Initiation of Antiplatelets in Patients with Acute Ischemic Stroke.
- Author:
Sun Ah PARK
1
;
Eun Young KIM
;
Sung Rye HA
;
Jeong Ho PARK
;
Tae Kyeong LEE
;
Ki Bum SUNG
;
Choon Sik PARK
Author Information
1. Department of Neurology, Soonchunhyang University College of Medicine, Bucheon, Korea. sapark@schbc.ac.kr
- Publication Type:Original Article
- Keywords:
Antiplatelets;
Cerebral infarction;
Flowcytometry;
Platelets
- MeSH:
Blood Platelets;
Cerebral Infarction;
Flow Cytometry;
Follow-Up Studies;
Humans;
P-Selectin*;
Stroke*
- From:Journal of the Korean Neurological Association
2006;24(3):210-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to evaluate the time course of PAC-1 and the P-selectin expression after the initiation of antiplatelets in acute ischemic stroke. METHODS: We serially measured PAC-1 and the P-selectin expression level using flow cytometry immediately before and at: one day, seven days, and one month after starting antiplatelets in 25 patients with acute cerebral infarctions. RESULTS: The P-selectin expression increased initially (p<0.05) and then from the seventh day, it began to decrease continually (post-hoc analysis, p<0.05). However, the PAC-1 expression did not reveal significant alterations during the follow-up period of one month. CONCLUSIONS: Although the P-selectin expression rapidly declined, the PAC-1 expression remained elevated for one month. Our results suggest that the P-selectin may be useful in monitoring platelet inhibition during the early period after cerebral infarction.
