Dissolution property of home-made and imported ambroxol hydrochloride tablets determined by HPLC and analyzed by Weibull's model
- VernacularTitle:国产与进口盐酸氨溴索片溶出度的HPLC法测定及Weibull分析
- Author:
Limei ZHANG
;
Zhuo WANG
;
Zhangwei YANG
;
Huixin XU
;
Jinhong HU
;
- Publication Type:Journal Article
- Keywords:
ambroxol hydrochloride;
dissolution property;
high performance liquid chromatography;
Weibull's model
- From:
Academic Journal of Second Military Medical University
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate dissolution properties of 2 kinds of ambroxol hydrochloride tablets.Methods: A HPLC method was used.The column was Hypersil C 18 (10 ?m,150 mm?4.6 mm).The mobile phase was methnol water tetrahydrofuran triethylamine (71∶29∶2.5∶0.25).The wavelength of detector was 242 nm.Data were analyzed by Weibull's distribution model.Results: Both tablets dissolved rapidly and their dissolution rate reached 85% in the first 8 min.But there was significant statistic differences between the 2 tablets as for Weibull's parameters.Conclusion: Although the dissolution rate of 2 tablets is similar,there are still some differences between their dissolution parameters.The dissolution of the imported tablets is more rapid than the home made ones.
