Effects of estradiol benzoate on the pathological changes of brain in 2VO-OVX rats
- VernacularTitle:雌二醇对慢性脑缺血去卵巢大鼠脑病理改变的影响
- Author:
Lusi LI
;
Xinghua WANG
;
Wenhui FAN
;
- Publication Type:Journal Article
- Keywords:
estradiol benzoate;
vascular dementia
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of estradiol benzoate on the morphology and number of neurons in cerebral frontal cortex and hippocampal CA1 area of 2VO OVX rats Methods Eighteen female Wistar rats were randomly divided into 3 groups, that is, sham operation, 2VO OVX (bilateral common carotid artery occlusion and ovariectomy)+ sesame oil, and 2VO OVX+estrogen replacement (named as S, O and E groups respectively) The changes of morphology and number of neurons in frontal cortex and hippocampal CA1 were studied with light and electron microscopy Results The numbers and shape of neurons in frontal cortex and CA1 were well maintained in E group, better than in O group but worse than in S group Significant differences were found in neuron number among 3 groups ( P
