Inhibitory effect of nitric oxide on hypertrophic response of cardiomyocytes stimulated by stretch in vitro
- VernacularTitle:一氧化氮抑制牵张刺激心肌细胞肥大反应的实验研究
- Author:
Min HUANG
;
Bing FENG
;
Yisheng CHEN
;
Zuoyun HE
;
- Publication Type:Journal Article
- Keywords:
nitric oxide;
stretch;
cardiocyte hypertrophy
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
3?10 -4 mol/L), and the role was persistent if its concentration was kept. Meanwhile, the increase of intracellular free Ca 2+ induced by stretch was also inhibited by NO. Conclusion Cardiocytes hypertrophic response stimulated by stretch could be inhibited by nitric oxide. The inhibitory effect might be due to the decrease of the concentration of intracellular free Ca 2+ .
