Effect of TGF-?1 on expression of INF-?-induced ?_2 M-in human pulmonary squamous cell carcinoma
- VernacularTitle:TGF-?_1对INF-?诱导肺鳞癌细胞?_2-M表达的影响
- Author:
Xiaojun ZHANG
;
Zuoxin LU
;
- Publication Type:Journal Article
- Keywords:
TGF? 1;
INF?;
? 2M;
FCM;
pulmonary squamous cell carcinoma;
primary cell culture
- From:Journal of Third Military Medical University
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of TGF? 1 on expression of MHCⅠ type antigen in human pulmonary squamous cell carcinoma.Methods Expressions of ? 2 M in primary culture cells with rhINF? and rhTGF? 1+rhINF? from human pulmonary squamous cell carcinoma were detected by FCM(Flow Cytometry Method), respectively. Results Expression of ? 2 M in all tumor cell groups was induced significantly by rhINF? ( P 0.05) Conclusion Expression of INF? induced MHCⅠ type antigen in human pulmonary squamous cell carcinoma can be inhibited by TGF? 1.
