Effect of valsartan and amlodipine on platelet activation and fibrinolytic activity in elderly patients with essential hypertension
- VernacularTitle:缬沙坦、氨氯地平对老年高血压病患者血小板活化及纤溶活性的影响及比较
- Author:
Shanling WANG
;
Lixia WANG
;
Yuehe SHUN
;
- Publication Type:Journal Article
- Keywords:
valsartan;
amlodipine;
hypertension;
platelet activation;
fibrinolytic activity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe platelet activation and fibrinolytic activity and evalute the effects of valsartan and amlodipine in elderly patients with essential hypertension. METHODS: Double antibody sandwich ELISA and spectrophotometric assay were used to examine the levels of platelet alpha granule membrane protein (GMP 140), tissue type plasminogen activator (t PA) and its inhibitor (PAI 1) in 57 elderly patients with essential hypertension and 30 normotensives. Valsartan was given in 29 cases (groupⅠ) and amlodipine in 28 cases (group Ⅱ) for 12 weeks. RESULTS: Elevated GMP 140, decreased t PA activity, and elevated PAI 1 activity were detected in the patients, but not in normotensives (P
