Immunologic effect of extra bacillus calmette guerin on asthmatic patients
- VernacularTitle:卡介苗素对支气管哮喘患者免疫调节作用
- Author:
Qianzhong LIU
;
Shiliang ZHOU
;
- Publication Type:Journal Article
- Keywords:
extra bacillus calmette guerin;
asthma;
interleukin 4;
interleukin 12
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the immunologic effect of extra bacillus calmette guerin (EBCG) on asthmatic patients. METHODS: 58 asthmatic patients in acute exacerbation were randomly enrolled into two groups: EBCG group (n=34) and control group (n=24). Before treatment, the levels of interleukin 4 (IL 4) and interleukin 12 (IL 12) in blood plasma were examined in both groups. The patients in EBCG group inhaled budesonide aerosol according to asthmatic ladder treatment program and injected with EBCG. Spasmolytic could be used if necessary (excluding theophylline) .The patients in control group only used budesonide aerosol and spasmolytic. The level of IL 4 and IL 12 in blood plasma were determined again after three months. RESULTS: After the drug intervention, the level of IL 4 significantly decreased in EBCG group ( 29.0 ? 5.6 vs 22.6 ? 6.5 ng?L -1 ,P 0.05 ). Before drug intervention, no significant differences were found between two groups in IL 4 and IL 12 concentrations; However, there were markedly differences after drug intervention (P
