Small conductance Calcium-activate potassium channel on neurons
- VernacularTitle:神经元上的小电导钙激活钾通道的研究进展
- Author:
Hongwei JIN
;
Xiaoliang WANG
;
- Publication Type:Journal Article
- Keywords:
small conductance Ca 2+ activated potassium channels(SK channels);
slow afterhyperpolarization;
CaM
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Small conductance Ca 2+ activated potassium channels ( SK channels) are potassium selective , voltage independent, and Ca 2+ high sensitivity. SK channels are widely distributed in neurons. SK underlie the slow afterhyperpolarization , which regulate the fire of neurons by spike frequency adaptation. Three mammalian SK channels (SK 1, SK 2, SK 3) have been cloned . Ca 2+ , CaM and neurotransimitters involve in the gating of these channels. The changes of these channels may result in memory, neuromuscular disorder and schizophrenia.
