Relation between animal models of RA and clinic
- VernacularTitle:类风湿关节炎动物模型与临床的关系
- Author:
Lingling ZHANG
;
Yuxian SHEN
;
Wei WEI
;
- Publication Type:Journal Article
- Keywords:
theumatoid artritis;
adjuvant arthritis;
collgen induced arthritis
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Animal models of rheumatoid arthritis(RA)especially adjuvant arthritis(AA)in rats and collagen induced arthritis(CIA)in mice have much character similar to human RA in pathological mechanism,clinical representation and so on. The models are more ideal in investigating RA and selecting drugs of anti inflammation and immunity. To discuss the pathological mechanism and the relation between animal models of RA and clinic will be important not only to research RA in pathology,physiology,nervous endocrine immunity and so on,but also to find out safety and effective drugs of treatment RA. The articl summarizes several animal models of RA in establishment,pathological and clinical changes,inflammatory immune regulation and so on.
