Effect of 3,4-oxo-isopropylidene-shikimic acidon free radical metabolism in the brain issue of rats subjected to middle cerebral artery thrombosis
- VernacularTitle:异亚丙基莽草酸对大脑中动脉栓塞大鼠脑组织自由基代谢的影响
- Author:
Hongtao WANG
;
Jianning SUN
;
Qiuping XU
;
Yajian GUO
;
- Publication Type:Journal Article
- Keywords:
ISA;
thrombosis;
cerebral artery;
cerebral ischemia;
free radical;
SOD;
MDA;
GSH px
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study effect of 3,4 oxo isopropylidene shikimic acid(ISA) on free radical metabolism in the brain issue of rats subjected to middle cerebral artery thrombosis.METHODS Adopt a middle cerebral artery thrombosis model to determine the activity of T SOD, Cu Zn SOD, MDA and GSH px of brain issue of rats by the way of colorimetry.RESULTS ISA 100 and 200 mg?kg -1 ig for 2 times in 24 hours raised the activity of T SOD;ISA 50, 100 and 200 mg?kg -1 ig,increased the activity of Cu Zn SOD and GSH px in rats brain issue ;ISA 50, 100 and 200 mg?kg -1 ig for 2 times in 24 hours,decreased the content of MDA in rats brain issue. CONCLUSIONS ISA protect brain issue from the ischemic damage by modifying the free radical metabolism.
