Low dose transdermal scopolamine increases cardiac vagal tone in patients with acute myocardial infarction
- VernacularTitle:小剂量东莨菪碱透皮治疗增加心肌梗死急性期心脏迷走神经张力
- Author:
Liuyi WANG
;
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
acute;
vagus;
scopolamine;
heart rate variability;
baroreflex sensitivity
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate whether transdermal scopolamine increased cardiac vagal activity in patients with acute myocardial infarction. METHODS: A random, double blind, and placebo contrast trial was performed. Measures of heart rate variability (HRV) in patients given drugs or placebo were obtained by electrocardiograph and digital 24 h Holter recording before and after treatment. Baroreflex sensitivity (BRS) was performed using the phenylephrine method. RESULTS: Patients of acute myocardial infarction with transdermal scopolamine showed a significant increase in HRV time domain parameters and BRS after treatment (P
