Experimental study of the hypoglycemic activity of cortex moutan polysaccharide-2b
- VernacularTitle:丹皮多糖-2b降血糖作用的实验研究
- Author:
Liping LIU
;
Hao HONG
;
Qinmao WANG
;
Chao LIU
;
Zhiping ZHAO
;
- Publication Type:Journal Article
- Keywords:
cortex moutan polysaccharide 2b (CMP 2b);
hypoglycemic activity;
diabetic model;
insulin resistance
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the hypoglycemic action of cortex moutan polysaccharide 2b (CMP 2b) and the its mechanism. METHODS: Some animal models in this study included the glucose induced hyperglycemic model in mice, the alloxan induced diabetic model in mice and rats, and the HCSS induced insulin resistance model in mice. Those models were used to investigate the effects of CMP 2b on blood glucose of normal and hyperglycemic model animals, on serum superoxide dismutase (SOD), serum insulin, glycated hemoglobin (GHb), and apolipoproteinA 1 (ApoA 1) in alloxan diabetic animals. RESULTS: CMP 2b significantly lowered the blood glucose in hyperglycemic mice and rats induced by glucose and alloxan. CMP 2b also raised the SOD and ApoA 1 level, decreased the GHb level in diabetic animals, and improved insulin resistance in mice. CONCLUSION: CMP 2b can control experimental hyperglycemia. Its mechanism is related to improving insulin sensitivity and enhancing the utilization of glucose in peripheral tissues.
