Clinical study of salbutamol combined with magnesium sulfate by nebulization in the treatment of paroxysmal asthma
- VernacularTitle:联合吸入硫酸镁及沙丁胺醇治疗哮喘的临床研究
- Author:
Changqiong XU
;
Jing YANG
;
Xingke MENG
;
- Publication Type:Journal Article
- Keywords:
asthma;
magnesium sulfate;
salbutamol;
nebulization
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the efficacy of salbutamol combined with magnesium sulfate by nebulization in the treatment of paroxysmal asthma. METHODS: All of 75 asthma patients were divided into three groups of A, B, and C (n=25): A group treated with 3 ml of 7.5 % isoosmotic magnesium sulfate solution and 3 ml of physiology saline 5 minutes later; B group treated with 3 ml of 0.1 % salbutamol solution and 3 ml of Physiology saline 5 minutes later; C group treated with 3 ml of 0.1 % salbutamol solution and 3 ml of 7.5 % isoosmotic magnesium sulfate solution 5 min later. Forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow (PEF) in the three groups were tested before and after the treatment 15 min respectively; systolic, diastolic, heart rates and respirations were tested between group A and group C as well. RESULTS: Significant differences were found in ratios (FVC%, FEV1%, PEF%) of actual indexes of lung function (FVC, FEV1, PEF) to the predicted indexes between before and after treatment in the three groups (P
